FiD is a great comic, lead me here. Also, if you do happen to go off and read it, check the comments too. Half the fun is the outrageous stories!

I can attest to that. I actually got here from there.
...Hrm. That looks like a glorious VS screen. ROUND 1... FIGHT!! Would NOT want to place bets on that match-up.

The One Piece team wins.

No one on the One Piece side actually qualifies as a valid target for the EoH, and only Twilight, Rainbow, and possibly Pinkie could stand up to the broken character of Luffy, Zoro, and Sanji (he'll be broken at some point). And once one of the others on the FiD side was nabbed, they'd back down.

Hmm...unless Twilight's player unintentionally makes a reference, causing the entire table on both sides to burst into laughter, and that leads to Twilight pulling something epic when no one's looking.

One thing you may have neglected to factor in is that the ponies have the elements of harmony. Did you see what those did to the would-be Big Bad?

I specifically stated that none of the One Piece team would be a valid target for the EoH (Elements of Harmony). They probably work in FiD the same way they work in the show, where they restore Harmony to the target.

But quite a few of the people on Luffy's crew exhibit the Harmony traits. It wouldn't touch them.

Based on this picture.
Laughter: Usopp; He spins tales to brighten everyone's mood.
Loyalty: Zoro; We all know why.
Honesty: Luffy; Calls 'em like he sees 'em.
Kindness: Sanji, but only to the ladies. :P
Kindness: Vivi; I'm actually not sure that this fits too well, but everyone else has the others covered much better.
Generosity: Sanji; He will feed anyone if they're hungry.
Magic: Nami; She does have the Sorcery Climatact, and girl's definitely a druid once she gets her hands on her clima tacts, have you seen her weather predictions? Girl's a witch.

Kindness totally work for Vivi. would work for Chopper as well.